NMDAR dependent intracellular responses associated with cocaine conditioned place preference behavior
نویسندگان
چکیده
منابع مشابه
Intracellular Mechanisms Associated with Cocaine Induced Conditioned Place Preference
Adviser: Shirzad Jenab, Ph.D. The development and maintenance of cocaine addiction and relapse after abstinence depend heavily on learned associations between environmental stimuli and the rewarding properties of the drug. Cocaine and other abused drugs activate intracellular signaling cascades throughout the mesocorticolimbic reward circuitry, leading to functional changes in brain structure. ...
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Positive social interaction could play an essential role in switching the preference of the substance dependent individual away from drug related activities. We have previously shown that conditioned place preference (CPP) for cocaine at the dose of 15 mg/kg and CPP for four 15-min episodes of social interaction were equally strong when rats were concurrently conditioned for place preference by...
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Metabotropic glutamate receptor 5 (mGluR5) null mutant (-/-) mice have been reported to totally lack the reinforcing or locomotor stimulating effects of cocaine. We tested mGluR5 -/and +/+ mice for their locomotor and conditioned placepreference response to cocaine. Unlike the previous finding, here we show that compared to mGluR5 +/+ mice, -/mice exhibit no difference in the locomotor response...
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Impaired social interaction is a hallmark symptom of many psychiatric disorders. In substance use disorders, impaired social interaction is triply harmful (a) because addicts increasingly prefer the drug of abuse to the natural reward of drug-free social interaction, thus worsening the progression of the disease by increasing their drug consumption, (b) because treatment adherence and, conseque...
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ژورنال
عنوان ژورنال: Behavioural Brain Research
سال: 2017
ISSN: 0166-4328
DOI: 10.1016/j.bbr.2016.09.047